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Medical Encyclopedia |
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Encyclopedia -> Disease -> C -> Cardiomyopathy
Causes and Risks: Cardiomyopathy can be caused by viral infections; heart attacks; alcoholism; long-term, severe hypertension (high blood pressure), or for other reasons not yet known.
Specific types of cardiomyopathy include: - Ischemic Cardiomyopathy: Secondary to heart attack(s), which in turn are secondary to coronary artery occlusions. Heart attacks leave scars in the heart muscle (myocardium); the affected myocardium is then unable to contribute to the heart pumping function. The larger the scars (or the more numerous the heart attacks), the higher the chance to develop ischemic cardiomyopathy.
- Idiopathic Cardiomyopathy: Idiopathic means that the cause is unknown. Usually, this term refers to dilated cardiomyopathy
- Dilated Cardiomyopathy: A global, usually idiopathic myocardial disorder characterized by a marked enlargement and inadequate function of the left ventricle. It may affect young people.
- Hypertrophic Cardiomyopathy: A disproportionate growth of the left muscle ventricle. Sometimes, the right ventricle is also affected. In up to 70% of cases, there is a familial occurrence.
- Alcoholic Cardiomyopathy: A type of dilated cardiomyopathy that usually begins about 10 years after sustained, heavy alcohol consumption. It may present not only with the typical signs of heart failure, but also with atrial fibrillation or other heart rhythm problem.
- Peripartum Cardiomyopathy: A dilated cardiomyopathy appearing in women during the last trimester of pregnancy, or after childbirth.
- Restrictive Cardiomyopathy: A disorder affecting the diastolic function of the heart. The heart cannot relax adequately after each contraction (systole), and thus it cannot be adequately filled with blood. Examples of restrictive cardiomyopathy are amyloidosis and sarcoidosis. Cardiomyopathy is not common but can be severely disabling or fatal. Extreme cardiomyopathy with heart failure may require a heart transplant.
Prevention: References: Louie EK, Edwards LC 3rd. Hypertrophic cardiomyopathy. Progress in Cardiovascular Diseases 1994; 36:275-308. Mandinov L, Eberli FR, Seiler C, Hess OM. Diastolic heart failure. Cardiovascular Research 2000; 45): 813-825. Felker GM, Thompson RE, Hare JM, et al. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. New England Journal of Medicine 2000; 342:1077-1084.
Symptoms: Additional Symptoms That May Occur:
Signs and Tests: Examination may reveal an irregular heartbeat; heart sounds and breath sounds may be abnormal. Additionally, there may be other signs of heart failure.
Decreased heart functioning and heart enlargement may appear in these tests: - Coronary Angiography: The study of the coronary arteries, (i.e., the vessels providing blood to the heart muscle). The angiography is done by introducing a catheter through the groin and making it ascend to the heart, then injecting a contrast solution to visualize the coronary arteries.
- Ecardiogram
- Chest X-ray
- Chest CT scan: Computerized tomography of the chest
- MRI of chest: Magnetic resonance imaging of the chest
- ECG: May show enlargement, old MI, ischemic changes, arrhythmias, or other abnormalities.
- A heart biopsy may be needed to rule out other disorders.
Lab tests may be used to rule out other disorders and to assess the condition of the heart: - CBC: Complete Blood Count. Red and white cells are counted, as well as platelets.
- Coronary Risk Profile: The patients risk factors for coronary disease are evaluated. Risk Factors include, but are not limited to, cigarette smoking, lipid profile (particularly cholesterol level), hypertension, diabetes, and physical inactivity.
- Blood Chemistries: CBC, lipid profile, and cardiac enzymes
Cardiac Enzymes: (CPK isoenzymes, CK-MB, LDH isoenzymes)
Treatment: While every cardiomyopathy may result in heart failure, each case requires specific strategies for recovery. Heart failure is treated with a vigorous blend of patient education, dietary changes, and medications. Possible treatments include: - Positive inotropic agents: These chemicals help the heart contract. The main agent of this category is digoxin. In-hospital options include dopamine, dobutamine, and milrinone.
- Diuretics: Often called "water pills," diuretics help relieve the fluid overloads in heart failure.
- Vasodilators: These drugs dilate vessels at several levels in the body, reducing the workload for the heart.
- ACE-inhibitors: These treatments act as vasodilators while helping to restore the hormonal balance
- Other drugs include: Angiotensin II receptor blockers, calcium channel blockers, beta-blockers, antiarrhythmic drugs, and anticoagulants.
- Advanced, severe heart failure requires heart transplantation.
- Palliative measures, which can be implemented when a donor becomes available, involve surgical procedures. They include:
- Left Ventricular Assist Device (LVAD): Treatment provides mechanical circulatory support.
- Dynamic Cardiomyoplasty: A procedure in which a skeletal muscle flap, created from a patients thoracic muscle, is trained to contract often and "wrapped around" the heart to help it contract
- Biventricular pacing: A pacemaker lead (i.e., cable) is inserted in each ventricle, left and right, to help the heart contract better.
Prognosis: The outcome varies. The disorder is chronic and the condition may deteriorate rapidly.
Complications: - heart failure
Go to the emergency room or call the local emergency number (such as 911) if symptoms indicate heart failure may be present, or if chest pain is present and not relieved by rest or medication.
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